Lumican

A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.

Also Known As:

Lumican Proteoglycan

Carbohydrates: 22516
- Polysaccharides: 15996
  - Proteoglycans: 4882
    - Small Leucine-Rich Proteoglycans: 193
      - Lumican: 266
- Glycoconjugates: 1370
  - Glycoproteins: 25180
    - Proteoglycans: 4882
      - Small Leucine-Rich Proteoglycans: 193
        Lumican: 266
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Glycoproteins: 25180
    - Proteoglycans: 4882
      - Small Leucine-Rich Proteoglycans: 193
        Lumican: 266
  - Scleroproteins: 75
    - Extracellular Matrix Proteins: 3213
      - Small Leucine-Rich Proteoglycans: 193
        Lumican: 266

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Disease

Drug/Important Bio-Agent (IBA)